Glandular odontogenic cyst is a rare developmental odontogenic cyst that bears similarity to several other odontogenic lesions. This lesion is categorised into three variants of which the more common variant is follicular type which is often mistaken for dentigerous cyst. Glandular odontogenic cyst goc is an uncommon jaw bone cyst of odontogenic origin, first described in 1988 by gardner et al. Hyperchromatic, cuboidal or columnar basal cell layer 3. The lesion has eroded the buccallabial cortical plate of the mandible. It is a cyst having an unpredictable and potentially aggressive behaviour. It also has the propensity to grow to a large size and tendency to recur with only 111 cases having been reported thus far. It is more common in adults in their fifth and sixth decades. Glandular odontogenic cyst and odontogenic cysts with mucous metaplasia. The general topic of head and neck pathology is covered in the head and neck pathology and head and neck cytopathology articles. The histopathology is very characteristic as it shows a stratified squamous epithelium that contains ductlike structures of glandular appearance and therefore it is known as glandular odontogenic cyst or sialoodontogenic cyst. A case report of glandular odontogenic cyst of mandible. The potentially aggressive nature of the lesion was suggested by penetration of the cortical bone and high incidence of recurrence after conservative treatment.
The glandular odontogenic cyst goc, though rare, has now become a well known entity. Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by. Glandular odontogenic cyst associated with impacted tooth. Glandular odontogenic cyst goc is a rare odontogenic cyst of the jaw bones, accounting for 0. This article covers odontogenic tumours and cysts, which is a subset of oral pathology and can be grouped under the heading of head and neck pathology the general topic of head and neck pathology is covered in the head and neck pathology and head and neck cytopathology articles the vast majority of oral malignancies are squamous cell carcinoma. It is a developmental jaw cyst with characteristic histopathological. Table 3 gender distribution of patients with odontogenic cysts included in a study in the college of dentistry, king saud university, riyadh, kingdom of saudi arabia. A case report jahanshah salehinejad1, shadi saghafi2, narges ghazi1 1 dental research center, department of oral and maxillofacial pathology, faculty of dentistry, mashhad university of medical sciences, mashhad, iran. Its origin is unknown, but some authors suggest it is associated with the remnants of dental lamina2. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development.
The occurrence of goc with ameloblastoma as a collision tumor is rarest, and such a case poses problems in the form of diagnostic dilemma and management. Cysts that derive their epithelium from tissues involved in tooth formation are classed odontogenic and can be inflammatory or developmental in origin. It usually presents as a slowgrowing, asymptomatic swelling generally affecting the anterior parts of jaws, particularly the mandible. The vast majority of oral malignancies are squamous cell carcinoma. Download file pdf investigative pathology of odontogenic cysts investigative pathology of odontogenic cysts. Glandular odontogenic cyst, histopathology and surgical treatment introduction glandular odontogenic cyst goc is an uncommon jaw bone cyst of odontogenic origin, first described as a distinct clinicopathologic entity in 1988 by gardner et al.
The cyst extends from the left molar region to the right premolar region and has a multiloculated, scalloped outline. Glandular odontogenic cyst was first described by padayachee and van wyk in 19871. Differential diagnosis of radiolucent lesions of the jaws. Glandular odontogenic cyst mimicking ameloblastoma in a 78. Locally aggressive developmental cyst occurring within the jaws, recognized by who in 1992 as odontogenic in origin noteworthy for locally aggressive growth, potential for recurrence and differential diagnostic considerations while generally accepted as odontogenic in origin, lesion demonstrates glandular features. Developmental jaw cyst, glandular cyst, recurrent cyst. Careful histopathological examination is needed to diagnose goc, and a careful longterm followup is advocated. Glandular odontogenic cyst goc is a rare and uncommon jaw bone cyst of odontogenic origin described in 1987 by gardener et al. In this article, we describe four cases of glandular odontogenic cyst. Glandular sialoodontogenic cyst anterior jaws pericoronal or multilocular adults tendency for recurrence after curettage stratified squamous lining with.
Glandular odontogenic cyst associated with ameloblastoma. Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial. This results in a cyst attached to the tooth at the cementenamel junction, with the crown enclosed in its lumen. Glandular odontogenic cyst was defined as a welldefined unilocular lesion on panoramic radiographs and multidetector computed tomography. Although only a few cases have been reported, it is worth mentioning due to its locally aggressive behavior and its propensity to recur. Transformation of a glandular odontogenic cyst into.
A glandular odontogenic cyst goc is a developmental cyst that is a clinically rare and histopathologically unusual type of odontogenic cyst. It is a cyst having an unpredictable, potentially aggressive behavior, and has the propensity to grow in large size with relatively high recurrence rate. Dentigerous cyst could be defined as an odontogenic cyst that envelops the crown of an unerupted tooth, caused due to accumulation of fluid between the reduced enamel epithelium and the enamel. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium. Odontogenic cysts that can be problematic because of recurrence andor aggressive growth include odontogenic keratocyst okc, calcifying.
Molecular diagnostics in the differential diagnosis of. Glandular odontogenic cyst isd imaging science in dentistry. Goc is often misdiagnosed because of its overlapping histopathological features with that of other odontogenic cysts such as lateral periodontal cyst lpc or. Pdf glandular odontogenic cyst goc is a rare and uncommon jaw bone cyst of. Ct image of a glandular odontogenic cyst in the anterior mandible.
In 1992, the world health organization who classified odontogenic tumors histologically and described goc as a cyst arising in the toothbearing areas of the jaws and characterized by an epithelial lining with cuboidal or. Odontogenic cysts that can be problematic because of recurrence andor aggressive growth include odontogenic keratocyst okc, calcifying odontogenic cyst, and the recently described glandular. The glandular odontogenic cyst is a rare develop mental cyst. Till 2017, only 169 such cases have been reported in the literature. On radiographs, it can appear as a unilocular or multilocular radiolucency dark area. In addition, this term was included in the revised edition of a world health organization report3 in 1992 as developmental odontogenic epithelial cyst. Symptoms, risk factors and treatments of glandular odontogenic cyst medical condition the glandular odontogenic cyst is a rare odontogenic. Adenomatoid odontogenic tumor aot is a wellrecognised slow growing benign tumor derived from complex system of dental lamina or its remnants. Glands of serres dental lamina odontogenic keratocyst glandular odontogenic cyst gingival cyst of infants gingival cyst of adults reduced enamel epithelium enamel organ dentigerous cyst eruption cyst lateral periodontal cyst botryoid odontogenic cyst table 2 minisymposium. We present a case of aot in a 14yearold male who was misdiagnosed as dentigerous cyst.
These cysts show variable features and some lie on a cysttumour interface, making classification and diagnosis difficult. Odontogenic cysts are largely classified based on their location, viability of the associated tooth and clinical setting. Mohammad khaja moinuddin abstract glandular odontogenic cyst goc is odontogenic in origin and is an uncommon jaw bone cyst, with a frequency rate ranging from 0. Glandular odontogenic cyst goc is known as a slowly growing, painless, but aggressive lesion. Lateral periodontal cyst glandular odontogenic cyst unclassified paradental cyst calcifying odontogenic cyst 9. Glandular odontogenic cyst medical condition youtube. Glandular odontogenic cyst international journal of applied dental. Glandular odontogenic cyst goc is an uncommon jaw cyst that arises from odontogenic origin and was first described by gardner et al. A glandular odontogenic cyst is a developmental cyst that is a clinically rare and histopathologically unusual type of odontogenic cyst. This article covers odontogenic tumours and cysts, which is a subset of oral pathology and can be grouped under the heading of head and neck pathology. The orthokeratinized odontogenic cyst ooc is a developmental odontogenic cyst relatively rare, arising from the cell rests of the dental lamina 1, 2. Cyst male female total apical radicular cyst 150 146 296 dentigerous cyst 82 36 118 glandular odontogenic cyst 2 3 5 residual cyst 27 4 31. Radiology and histopathology calcifying odontogenic cyst coc was first described by gorlin in 1962.
The glandular odontogenic cyst was first described in 1987. We present a case of a patient with a cyst located in the anterior mandible, which was treated with curettage and. Glandular odontogenic cyst goc is a relatively new entity and is defined as a cyst arising in the toothbearing areas of the jaws and characterized by an epithelial lining with cuboidal or columnar cells, both at the surface and lining, with crypts or cystlike spaces within the thickness of the epithelium. Odontogenic cysts, tumors, and related jaw lesions. A dentigerous cyst results because of the enlargement of the follicular space of the whole or part of the crown of an impacted or. Histopathology showed a cyst lined by multilayered cuboidal epithelium, with a superficial layer of pale eosinophilic cells, resembling hobnails. Glandular odontogenic cyst, histopathology and surgical treatment. Glandular odontogenic cyst goc is an uncommon jaw bone cyst of odontogenic origin described in 1987 by gardner et al. The glandular odontogenic cyst is a rare odontogenic cyst.
Careful histopathological examination is needed to diagnose goc, and a. Odontogenic cysts, tumors, and related jaw lesions ento key. Glandular odontogenic cyst goc is an uncommon jaw bone cyst. The glandular odontogenic cyst goc has two clinically important attributes. Glandular odontogenic cyst goc, accepted by who 1992 sialoodontogenic cyst polymorphous odontogenic cyst mucoepidermoid odontogenic cyst epidemiology. It was first described by schultz in 1927 as an orthokeratinized variant of the formerly called odontogenic keratocyst, today known as the keratocystic odontogenic tumour. Odontogenic cysts, odontogenic tumors, fibroosseous, and. Glandular odontogenic cyst the glandular odontogenic cyst goc is a rare lesion, accounting for just 0.
Department of oral pathology, nims dental college and. In 85% of cases, it is found in the mandible, especially in anterior areas. The study should represent a complete collection of. The glandular odontogenic cyst goc is a rare entity with around 111 cases available in the literature.